Therapeutic challenge of a patient about 40 years ago initiated the development of ultrafiltrates of fetal and juvenile organs. An 8 years old girl sustained deep burn of the upper right side of the body, caused by an explosion of a petroleum stove. A disfiguring hypertrophic scar developed on the neck and face (fig.1). The attempt to eliminate the ½” thick hypertrophic scar with contracture by applying specially prepared cell extract from fetal skin and placenta was successful.

After such success the cell extracts from skin and placenta were applied to other patients with severe deep burns, untreatable by other means. In field tests in Switzerland and Germany the therapeutic range of application of various ultrafiltrates was tested and a number of further indications were established.

After the absorption of fetal ultrafiltrates through the intact skin was proven, their epithelialising effect was demonstrated by impressive histological study of F. Leyh in 1981- 1983. If skin permitted the absorption of ultrafiltrates it was logical to anticipate that the mucosa will permit transport of ultrafiltrates of any & all organs and tissues into the organism even better than skin. An oral method of administration of ultrafiltrates was born when positive therapeutic effect was observed. A preparation of a combination of ultrafiltrates of liver, pancreas, placenta, stomach, intestinal, mucosa was developed next to assist in regeneration of damaged intestinal mucosa and in treatment of metabolic diseases. Central nervous system ultrafiltrate was created next.
The observed responses led to the design of combinations of ultrafiltrates of various organs and tissues for biological regeneration of disordered organ systems.